hnrnp h การใช้

• Interestingly enough, tumorous cells often overexpress hnRNP H . When hnRNP H is downregulated, the A-RAF gene is alternatively spliced.
• Interestingly enough, tumorous cells often overexpress hnRNP H . When hnRNP H is downregulated, the A-RAF gene is alternatively spliced.
• However, this inhibition is only possible when the splice factor heterogenous nuclear ribonucleoprotein H ( hnRNP H ) maintains the expression of a full-length A-Raf protein.
• Thus, overexpression of hnRNP H in tumor cells leads to full-length expression of A-Raf which then inhibits apoptosis, allowing cancerous cells that should be destroyed to stay alive.